Alexander Bukreyev Selected Research

N- ((1R)- 6- chloro- 2,3,4,9- tetrahydro- 1H- carbazol- 1- yl)- 2- pyridinecarboxamide

10/2018

Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses.

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Alexander Bukreyev Research Topics

Disease

53	Infections 12/2023 - 08/2002
15	COVID-19 12/2023 - 01/2021
8	Paramyxoviridae Infections (Parainfluenza) 04/2022 - 12/2002
7	Ebola Hemorrhagic Fever 01/2021 - 01/2016
5	Virus Diseases (Viral Diseases) 01/2023 - 08/2002
5	Filoviridae Infections 11/2021 - 01/2017
4	Inflammation (Inflammations) 11/2021 - 08/2005
4	Weight Loss (Weight Reduction) 10/2021 - 05/2010
4	Respiratory Syncytial Virus Infections 04/2013 - 09/2003
3	Severe Acute Respiratory Syndrome 03/2024 - 06/2004
3	Hantavirus Infections 01/2023 - 01/2021
3	Vesicular Stomatitis 07/2021 - 01/2018
3	Dengue (Dengue Fever) 10/2020 - 12/2002
2	Vaccinia 07/2022 - 01/2020
2	Lymphopenia (Lymphocytopenia) 10/2021 - 01/2017
2	Asymptomatic Infections 01/2021 - 01/2021
2	Marburg Virus Disease 10/2020 - 01/2020
2	Viremia 01/2017 - 03/2006
2	Cytokine Release Syndrome 01/2017 - 01/2017
2	Fever (Fevers) 08/2015 - 03/2006
2	Reinfection 04/2013 - 04/2010
2	Influenza in Birds (Avian Flu) 02/2010 - 11/2007
2	Human Influenza (Influenza) 01/2005 - 12/2002
1	Renal Insufficiency (Renal Failure) 01/2023
1	Convalescence 12/2022
1	Rabies (Hydrophobia) 01/2021
1	Lung Diseases (Lung Disease) 01/2021
1	Neoplasms (Cancer) 01/2017
1	Bites and Stings (Sting) 01/2017
1	Sepsis (Septicemia) 01/2017

Drug/Important Bio-Agent (IBA)

30	VaccinesIBA 03/2024 - 08/2002
16	AntibodiesIBA 12/2023 - 06/2004
12	Monoclonal AntibodiesIBA 10/2022 - 01/2018
12	Proteins (Proteins, Gene)FDA Link 11/2021 - 09/2003
11	Glycoproteins (Glycoprotein)IBA 04/2023 - 08/2008
9	Neutralizing AntibodiesIBA 12/2023 - 11/2007
7	CytokinesIBA 01/2017 - 08/2005
5	Immunoglobulin G (IgG)IBA 12/2022 - 01/2018
5	AntigensIBA 10/2021 - 11/2005
4	EpitopesIBA 01/2023 - 01/2018
4	Attenuated VaccinesIBA 07/2022 - 12/2002
4	RNA (Ribonucleic Acid)IBA 01/2021 - 10/2018
3	Messenger RNA (mRNA)IBA 01/2023 - 04/2010
3	DNA (Deoxyribonucleic Acid)IBA 10/2020 - 01/2017
3	Polysaccharides (Glycans)IBA 01/2019 - 01/2018
3	Antiviral Agents (Antivirals)IBA 01/2018 - 01/2017
3	InterferonsIBA 01/2017 - 04/2013
3	Interleukin-4 (Interleukin 4)IBA 05/2010 - 08/2005
2	mRNA VaccinesIBA 03/2024 - 12/2023
2	Immunoglobulin A (IgA)IBA 12/2022 - 01/2021
2	COVID-19 VaccinesIBA 04/2022 - 12/2021
2	Fc Receptors (Fc Receptor)IBA 11/2021 - 01/2018
2	erythromycin propionate-N-acetylcysteinateIBA 11/2021 - 09/2020
2	von Willebrand FactorIBA 11/2021 - 09/2020
2	Cyclic AMP Receptors (Cyclic AMP Receptor)IBA 11/2021 - 09/2020
2	2019-nCoV Vaccine mRNA-1273IBA 10/2021 - 01/2021
2	Ebola VaccinesIBA 01/2021 - 01/2019
2	Type I DNA Topoisomerases (Topoisomerase I)IBA 10/2020 - 03/2020
2	Toll-Like Receptor 4IBA 11/2018 - 01/2017
2	ChemokinesIBA 01/2017 - 01/2017
2	Neuraminidase (Sialidase)IBA 02/2010 - 01/2005
2	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 06/2007 - 12/2002
1	1E7-03 compoundIBA 06/2023
1	cobra venom factorIBA 04/2023
1	Complement System Proteins (Complement)IBA 04/2023
1	5-amino-5-deoxymannopyranosideIBA 12/2022
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022
1	CC-90009IBA 01/2022
1	Small Interfering RNA (siRNA)IBA 01/2022
1	Interleukin-17 (Interleukin 17)IBA 01/2022
1	Matrix Metalloproteinase 10 (Stromelysin 2)IBA 01/2022
1	COVA1-18IBA 10/2021
1	SARS-CoV-2 spike proteinIBA 07/2021
1	odesivimabIBA 01/2021
1	maftivimabIBA 01/2021
1	ansuvimabIBA 01/2021
1	CoraVax COVID-19 vaccineIBA 01/2021
1	atoltivimabIBA 01/2021
1	Adenosine Monophosphate (AMP)IBA 09/2020
1	MicroRNAs (MicroRNA)IBA 01/2020
1	Annexin A2 (Annexin II)IBA 01/2020
1	MucinsIBA 01/2019
1	Immune Sera (Antisera)IBA 01/2019
1	CalciumIBA 11/2018
1	Viral RNAIBA 10/2018
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 10/2018
1	N- ((1R)- 6- chloro- 2,3,4,9- tetrahydro- 1H- carbazol- 1- yl)- 2- pyridinecarboxamideIBA 10/2018
1	brequinarIBA 10/2018
1	Dihydroorotate DehydrogenaseIBA 10/2018
1	ZMappIBA 01/2018
1	Combined Antibody TherapeuticsIBA 01/2018
1	Immunoglobulin Fc FragmentsIBA 01/2018
1	Tolcapone (Tasmar)FDA Link 10/2017
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2017
1	Phosphotransferases (Kinase)IBA 01/2017
1	PhosphatidylserinesIBA 01/2017
1	Hepatitis A Virus Cellular Receptor 1IBA 01/2017
1	Free RadicalsIBA 01/2017
1	eritoranIBA 01/2017

Therapy/Procedure

6	Therapeutics 01/2023 - 05/2016